KCNK2 Rabbit Polyclonal Antibody (ER1902-06)

UNIPROT #

O95069

PROTEIN NAME

KCNK2

SYNONYMS

hTREK 1c antibody;hTREK 1e antibody;K2p2.1 antibody;K2P2.1 potassium channel antibody;KCNK 2 antibody;Kcnk2 antibody;KCNK2_HUMAN antibody;MGC126742 antibody;MGC126744 antibody;Outward rectifying potassium channel protein TREK 1 antibody;Outward rectifying potassium channel protein TREK-1 antibody;Outward rectifying potassium channel protein TREK1 antibody;Potassium channel subfamily K member 2 antibody;Potassium inwardly rectifying channel subfamily K member 2 antibody;Tandem pore domain potassium channel TREK 1 antibody;Tandem pore domain potassium channel TREK1 antibody;TPKC1 antibody;TREK 1 antibody;TREK 1 K(+) channel subunit antibody;TREK antibody;TREK-1 K(+) channel subunit antibody;TREK1 antibody;TWIK related potassium channel 1 antibody;Two pore domain potassium channel TREK 1 antibody;Two pore domain potassium channel TREK-1 antibody;Two pore domain potassium channel TREK1 antibody;Two pore potassium channel 1 antibody;Two pore potassium channel TPKC1 antibody

SEQUENCE SIMILARITIES

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

TISSUE SPECIFICITY

Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.

SUBCELLULAR LOCATION

Cell membrane, Endoplasmic reticulum.

FUNCTION

Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).