Rabbit polyclonal primary
KCNK2 Rabbit Polyclonal Antibody (ER1902-06)
Synthetic peptide corresponding to n terminal of human kcnk2.
Rat brain lysates, rat adrenaline tissue, human liver tissue, human kidney tissue, mouse brain tissue, A549.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
hTREK 1c antibody; hTREK 1e antibody; K2p2.1 antibody; K2P2.1 potassium channel antibody; KCNK 2 antibody; Kcnk2 antibody; KCNK2_HUMAN antibody; MGC126742 antibody; MGC126744 antibody; Outward rectifying potassium channel protein TREK 1 antibody; Outward rectifying potassium channel protein TREK-1 antibody; Outward rectifying potassium channel protein TREK1 antibody; Potassium channel subfamily K member 2 antibody; Potassium inwardly rectifying channel subfamily K member 2 antibody; Tandem pore domain potassium channel TREK 1 antibody; Tandem pore domain potassium channel TREK1 antibody; TPKC1 antibody; TREK 1 antibody; TREK 1 K(+) channel subunit antibody; TREK antibody; TREK-1 K(+) channel subunit antibody; TREK1 antibody; TWIK related potassium channel 1 antibody; Two pore domain potassium channel TREK 1 antibody; Two pore domain potassium channel TREK-1 antibody; Two pore domain potassium channel TREK1 antibody; Two pore potassium channel 1 antibody; Two pore potassium channel TPKC1 antibody
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra.
Phosphorylation at Ser-348 controls the reversible conversion from a leak channel to a voltage-dependent channel.
Cell membrane, Endoplasmic reticulum.
Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).