KCNK18 Rabbit Polyclonal Antibody (ER1901-46)

UNIPROT #

Q7Z418

PROTEIN NAME

KCNK18

SYNONYMS

K2p18.1 antibody;KCNK18 antibody;KCNKI_HUMAN antibody;MGR13 antibody;OTTHUMP00000020575 antibody;Potassium channel subfamily K member 18 antibody;TRESK 2 antibody;TRESK antibody;TRESK2 antibody;TRIK antibody;TWIK related individual K+ channel antibody;TWIK related individual potassium channel antibody;TWIK related spinal cord K+ channel antibody;TWIK related spinal cord potassium channel antibody;TWIK-related individual potassium channel antibody;TWIK-related spinal cord potassium channel antibody

SEQUENCE SIMILARITIES

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

TISSUE SPECIFICITY

Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation of Ser-252 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-264 enhances channel activity (By similarity).; N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.