KChIP1 Rabbit Polyclonal Antibody (ER1902-17)

UNIPROT #

Q9NZI2

PROTEIN NAME

KChIP1

SYNONYMS

A type potassium channel modulatory protein 1 antibody;A-type potassium channel modulatory protein 1 antibody;KChIP1 antibody;KCIP1_HUMAN antibody;Kcnip1 antibody;Kv channel interacting protein 1 antibody;Kv channel-interacting protein 1 antibody;MGC9 antibody;MGC95 antibody;Potassium channel interacting protein 1 antibody;Potassium channel-interacting protein 1 antibody;VABP antibody;Vesicle APC binding protein antibody;Vesicle APC-binding protein antibody

SEQUENCE SIMILARITIES

Belongs to the recoverin family.

TISSUE SPECIFICITY

Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.

SUBCELLULAR LOCATION

Cell membrane, cytoplasm, dendrite.

FUNCTION

This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms.