KChIP1 Rabbit Polyclonal Antibody (ER1902-17)
Catalog# ER1902-17
Rabbit Polyclonal to KChIP1
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WB
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IHC-P
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FC
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Human
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
KChIP1 Rabbit Polyclonal Antibody (ER1902-17)
Immunogen
Synthetic peptide within human kchip1 aa 1-50 / 227.
Host
Rabbit
Positive Control
Human skin tissue lysates, rat brain tissue, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:500
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IHC-P:1:50-1:100
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FC:1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size 27 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
KChIP1
SYNONYMS
A type potassium channel modulatory protein 1 antibody;A-type potassium channel modulatory protein 1 antibody;KChIP1 antibody;KCIP1_HUMAN antibody;Kcnip1 antibody;Kv channel interacting protein 1 antibody;Kv channel-interacting protein 1 antibody;MGC9 antibody;MGC95 antibody;Potassium channel interacting protein 1 antibody;Potassium channel-interacting protein 1 antibody;VABP antibody;Vesicle APC binding protein antibody;Vesicle APC-binding protein antibody
SEQUENCE SIMILARITIES
Belongs to the recoverin family.
TISSUE SPECIFICITY
Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.
SUBCELLULAR LOCATION
Cell membrane, cytoplasm, dendrite.
FUNCTION
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms.
CITATIONS
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Pan, B., Kong, F., Ju, X., Song, J., Wang, L., Niu, Q., & Lu, X.
Molecular mechanism of the carboxyl terminus of Hsc70-interacting protein in TAU hyperphosphorylation induced by AlCl3 in N2a cells
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WB
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Mouse
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Citation
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