K27-linkage Specific Ubiquitin Recombinant Rabbit Monoclonal Antibody [JE75-30] (HA723066)

UNIPROT #

P0CG47

PROTEIN NAME

K27-linkage Specific Ubiquitin

SYNONYMS

Epididymis secretory protein Li 50 antibody;FLJ25987 antibody;HEL S 50 antibody;MGC8385 antibody;Polyubiquitin B antibody;RPS 27A antibody;RPS27A antibody;UBA 52 antibody;UBA 80 antibody;UBA52 antibody;UBA80 antibody;UBB antibody;UBB_HUMAN antibody;UBC antibody;UBCEP 1 antibody;UBCEP 2 antibody;UBCEP1 antibody;UBCEP2 antibody;Ubiquitin antibody;Ubiquitin B antibody

SUBCELLULAR LOCATION

Cell Membrane, Cytoplasmic and Nuclear

FUNCTION

Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Similarity: Belongs to the ubiquitin family. Contains 3 ubiquitin-like domains.