PRODUCT CODE: 0407-9

Junctophilin-2 Rabbit Polyclonal Antibody (0407-9)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

  • Rat

Western blot analysis on mouse heart using anti-JPH-2 polyclonal antibody.
  • Western blot analysis on mouse heart using anti-JPH-2 polyclonal antibody.
Western blot analysis on mouse heart using anti-JPH-2 polyclonal antibody.

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Junctophilin-2 Rabbit Polyclonal Antibody (0407-9)

Immunogen

Peptide

Host

Rabbit

Positive Control

Mouse heart

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

94/74kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:2000

TARGET

UNIPROT #

PROTEIN NAME

Junctophilin-2

SYNONYMS

FLJ40969 antibody; JP-2 antibody; JP2 antibody; Jph2 antibody; JPH2_HUMAN antibody; Junctophilin 2 antibody; Junctophilin type 2 antibody; Junctophilin-2 antibody; OTTHUMP00000031651 antibody; OTTHUMP00000031652 antibody

SEQUENCE SIMILARITIES

Belongs to the junctophilin family.

TISSUE SPECIFICITY

Specifically expressed in skeletal muscle and heart.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Ser-165, probably by PKC, affects RYR1-mediated calcium ion release, interaction with TRPC3, and skeletal muscle myotubule development.; Proteolytically cleaved by calpain in response to cardiac stress. The major cleavage site takes place at the C-terminus and leads to the release of the Junctophilin-2 N-terminal fragment chain (JP2NT).

SUBCELLULAR LOCATION

Cell membrane, ER membrane

FUNCTION

Junctophilin-2 (JPH2) is a cardiac specific member of the junctophilins, a newly characterized family of junctional membrane complex proteins important in physically approximating the plasmalemmal L-type calcium channel and the sarcoplasmic reticulum ryanodine receptor for calcium-induced calcium release. It acts probably by anchoring the plasma membrane and endoplasmic reticulum. JPH2 contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development.