Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Western blot analysis of JunB on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (ET1612-57, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.
Lane 1: MCF-7 cell lysate
Lane 2: SiHa cell lysate
Lane 3: U937 cell lysate
Lane 4: THP-1 cell lysate
Activator protein 1 antibody;AP 1 antibody;AP1 antibody;Jun B antibody;Jun B proto oncogene antibody;Jun B protooncogene antibody;Junb antibody;JunB proto oncogene antibody;JunB protoncogene 9 antibody;JunB protooncogene antibody;JUNB_HUMAN antibody;Transcription factor jun B antibody;Transcription factor jun-B antibody;Transcription factor junB antibody
Belongs to the bZIP family. Jun subfamily.
Ubiquitinated by ITCH, leading to its degradation.
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.