JNK2 Recombinant Rabbit Monoclonal Antibody [SC05-85] (ET1610-11)

UNIPROT #

P45984

PROTEIN NAME

JNK2

SYNONYMS

c Jun kinase 2 antibody;C Jun N terminal kinase 2 antibody;c-Jun N-terminal kinase 2 antibody;JNK 55 antibody;JNK-55 antibody;JNK2 alpha antibody;JNK2 antibody;JNK2 beta antibody;JNK2A antibody;JNK2alpha antibody;JNK2B antibody;JNK2BETA antibody;Jun kinase antibody;MAP kinase 9 antibody;MAPK 9 antibody;Mapk9 antibody;Mitogen activated protein kinase 9 antibody;Mitogen-activated protein kinase 9 antibody;MK09_HUMAN antibody;P54a antibody;p54aSAPK antibody;PRKM9 antibody;Protein kinase, mitogen-activated, 9 antibody;SAPK alpha antibody;SAPK antibody;SAPK1a antibody;Stress activated protein kinase 1a antibody;Stress-activated protein kinase JNK2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1α1, JNK1β1, JNK2α1, JNK2β1, and JNK3α1, which represent the p46 isoforms, and JNK1α2, JNK1β2, JNK2α2, JNK2β2, and JNK3β2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.