JMJD6 Recombinant Rabbit Monoclonal Antibody [PSH15-03] (HA723703)

UNIPROT #

Q6NYC1

PROTEIN NAME

JMJD6

SYNONYMS

Apoptotic cell clearance receptor antibody;Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody;Histone arginine demethylase JMJD6 antibody;JmjC domain-containing protein 6 antibody;JMJD 6 antibody;JMJD6 antibody;JMJD6_HUMAN antibody;Jumonji domain containing 6 antibody;Jumonji domain-containing protein 6 antibody;KIAA0585 antibody;Lysyl-hydroxylase JMJD6 antibody;Peptide-lysine 5-dioxygenase JMJD6 antibody;Phosphatidylserine receptor antibody;Protein PTDSR antibody;PSR antibody;PTDSR 1 antibody;PTDSR antibody;PTDSR1 antibody

SUBCELLULAR LOCATION

Nucleus, nucleoplasm, nucleolus, Cytoplasm.

FUNCTION

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 is an enzyme that in humans is encoded by the JMJD6 gene. This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins belong to the alpha-ketoglutarate-dependent hydroxylase superfamily. They are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells. Subsequent studies suggest that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene. On a physiological level JMJD6 has a role in angiogenesis, the process of vessel formation, whereas further roles of JMJD6 in pathophysiological processes were implicated, such as mammary tumorigenesis. Here, elevated JMJD6 level were found in breast cancer associated with aggressiveness and metastasis in mice.