JAK3 Recombinant Rabbit Monoclonal Antibody [JM66-31] (ET1705-1)

UNIPROT #

P52333

PROTEIN NAME

JAK3

SYNONYMS

EC 2.7.10.2 antibody;JAK 3 antibody;JAK L antibody;JAK-3 antibody;Jak3 antibody;JAK3 HUMAN antibody;JAK3_HUMAN antibody;JAKL antibody;Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody;Janus kinase 3 antibody;Janus Kinase3 antibody;L JAK antibody;L-JAK antibody;Leukocyte janus kinase antibody;LJAK antibody;Protein tyrosine kinase leukocyte antibody;Tyrosine protein kinase JAK3 antibody;Tyrosine-protein kinase JAK3 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

TISSUE SPECIFICITY

In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated in response to IL-2 and IL-4. Dephosphorylation of Tyr-980 and Tyr-981 by PTPN2 negatively regulates cytokine-mediated signaling (Probable).

SUBCELLULAR LOCATION

Endomembrane system, Cytoplasm.

FUNCTION

Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene. As JAK3 is expressed in hematopoietic and epithelial cells, its role in cytokine signaling is thought to be more restricted than other JAKs. It is most commonly expressed in T cells and NK cells, but has also been found in intestinal epithelial cells. JAK3 is involved in signal transduction by receptors that employ the common gamma chain (γc) of the type I cytokine receptor family (e.g. IL-2R, IL-4R, IL-7R, IL-9R, IL-15R, and IL-21R). Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease), while activating Janus kinase 3 mutations lead to the development of leukemia. In addition to its well-known roles in T cells and NK cells, JAK3 has been found to mediate IL-8 stimulation in human neutrophils. IL-8 primarily functions to induce chemotaxis in neutrophils and lymphocytes, and JAK3 silencing severely inhibits IL-8-mediated chemotaxis.