Recombinant Rabbit monoclonal primary
IRF6 Recombinant Rabbit Monoclonal Antibody [SD202-6] (ET1612-36)
K562, MCF-7, 293, SW480, human kidney tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Interferon regulatory factor 6 antibody; IRF 6 antibody; IRF-6 antibody; IRF6 antibody; IRF6_HUMAN antibody; LPS antibody; OFC 6 antibody; OFC6 antibody; OTTHUMP00000034677 antibody; OTTHUMP00000034678 antibody; PIT antibody; PPS antibody; PPS1 antibody; VWS antibody; VWS1 antibody
Belongs to the IRF family.
Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP).