IRAK-1 Rabbit Polyclonal Antibody (HA500377)

UNIPROT #

P51617

PROTEIN NAME

IRAK-1

SYNONYMS

AA48924 antibody;Il1rak antibody;Interleukin 1 receptor associated kinase 1 antibody;Interleukin-1 receptor-associated kinase 1 antibody;IRAK antibody;IRAK-1 antibody;Irak1 antibody;IRAK1-S antibody;IRAK1_HUMAN antibody;mPLK antibody;OTTHUMP00000026014 antibody;OTTHUMP00000026015 antibody;OTTHUMP00000026020 antibody;OTTHUMP00000180621 antibody;Pelle antibody;Pelle homolog antibody;Pelle-like protein kinase antibody;Plpk antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.