Integrin alpha E Recombinant Rabbit Monoclonal Antibody [SN62-06] (ET1611-27)

UNIPROT #

P38570

PROTEIN NAME

Integrin alpha E

SYNONYMS

A530055J10 antibody;alpha-E1 antibody;alpha-M290 antibody;aM290 antibody;Antigen CD103 antibody;CD 103 antibody;CD103 antibody;CD103 antigen antibody;HML 1 antigen antibody;HML-1 antigen antibody;HML1 antigen antibody;Human mucosal lymphocyte antigen 1 antibody;Human mucosal lymphocyte antigen 1, alpha subunit antibody;Huminae antibody;Integrin alpha E heavy chain antibody;Integrin alpha E light chain antibody;Integrin alpha E, epithelial-associated antibody;Integrin alpha E1 antibody;Integrin alpha IEL antibody;Integrin alpha M290 antibody;Integrin alpha-E heavy chain antibody;Integrin alpha-IEL antibody;Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) antibody;Integrin, alpha E antibody;ITAE_HUMAN antibody;Itgae antibody;MGC141996 antibody;MGC183601 antibody;Mucosal lymphocyte 1 antigen antibody;Mucosal lymphocyte antigen 1 antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

TISSUE SPECIFICITY

Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. The αEβ7 complex is often referred to as "CD103" though this strictly refers only to the αE chain. Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d). The chief ligand for αEβ7 is E-cadherin, a cellular adhesion molecule (CAM) found on epithelial cells. It is probably important for T cell homing to the intestinal sites and thymocyte contacts with thymic reticuloepithelial cells. Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4+/CD25+/Foxp3+ cells. Some CD4+/FoxP3− cells also express CD103 and have been attributed regulatory activity.