Integrin alpha 3 Rabbit Polyclonal Antibody (HA500111)

UNIPROT #

P26006

PROTEIN NAME

Integrin alpha 3

SYNONYMS

AA407068 antibody;Antigen identified by monoclonal antibody J143 antibody;CD49 antigen like family member C antibody;CD49 antigen-like family member C antibody;CD49c antibody;CD49c antigen antibody;FLJ34631 antibody;FLJ34704 antibody;FRP 2 antibody;FRP-2 antibody;FRP2 antibody;Galactoprotein B3 antibody;GAP B3 antibody;GAPB3 antibody;Integrin alpha 3 antibody;Integrin alpha-3 light chain antibody;Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) antibody;ITA3_HUMAN antibody;ITGA 3 antibody;Itga3 antibody;MSK18 antibody;VCA 2 antibody;VCA2 antibody;Very late activation protein 3 receptor alpha 3 subunit antibody;VL3A antibody;VLA 3 alpha chain antibody;VLA 3 subunit alpha antibody;VLA-3 subunit alpha antibody;VLA3a antibody

SUBCELLULAR LOCATION

Cell membrane, invadopodium membrane, filopodium membrane.

FUNCTION

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3'). Expression of this gene may be correlated with breast cancer metastasis.