Lane 1: zebrafish
Lane 2: Hela
Lane 3: K562
Recombinant Rabbit monoclonal primary
Insulin degrading enzyme Recombinant Rabbit Monoclonal Antibody [JJ0949] (ET1701-97)
K562, Hela, zebrafish, human liver cancer tissue, human colon cancer tissue, human gastric carcinoma tissue, mouse colon tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Insulin degrading enzyme
Abeta-degrading protease antibody; FLJ35968 antibody; Ide antibody; IDE_HUMAN antibody; Insulin protease antibody; Insulin-degrading enzyme antibody; Insulinase antibody; Insulysin antibody; OTTHUMP00000020097 antibody
Belongs to the peptidase M16 family.
Detected in brain and in cerebrospinal fluid (at protein level).
The N-terminus is blocked.
Cytoplasm, Cell membrane, Secreted.
Insulin degrading enzyme (IDE), also known as insulinase, insulin protease or insulysin, cleaves the peptide hormone insulin with consequences for insulin response and resistance. IDE is a highly conserved thiol metalloprotease with ubiquitous expression including the brain. Since its discovery, IDE has been shown to degrade a variety of bioactive peptides. Recently the finding that IDE clears intracellular and extracellular amyloid products has spurred research into the link between IDE function and human neurodegenerative disease such as Alzheimer’s.