IMP3 Recombinant Rabbit Monoclonal Antibody [JE34-04] (HA721990)

UNIPROT #

O00425

PROTEIN NAME

IMP3

SYNONYMS

Cancer/testis antigen 98 antibody;CT98 antibody;DKFZp686F1078 antibody;hKOC antibody;IF2B3_HUMAN antibody;IGF II mRNA binding protein 3 antibody;IGF-II mRNA-binding protein 3 antibody;IGF2 mRNA binding protein 3 antibody;IGF2 mRNA-binding protein 3 antibody;IGF2BP3 antibody;IMP 3 antibody;IMP-3 antibody;Insulin like growth factor 2 mRNA binding protein 3 antibody;Insulin-like growth factor 2 mRNA-binding protein 3 antibody;KH domain containing protein overexpressed in cancer antibody;KH domain-containing protein overexpressed in cancer antibody;KOC 1 antibody;KOC1 antibody;VICKZ 3 antibody;VICKZ family member 3 antibody;VICKZ3 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, P-body, Stress granule.

FUNCTION

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.