Rabbit polyclonal primary
IL4 Rabbit Polyclonal Antibody (ER1706-55)
Recombinant protein lysate, human spleen tissue, human breast cancer tissue, mouse colon tissue, mouse small intestine tissue, Jurkat.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
B cell growth factor 1 antibody; B cell IgG differentiation factor antibody; B Cell Stimulatory Factor 1 antibody; B-cell stimulatory factor 1 antibody; BCGF 1 antibody; BCGF1 antibody; Binetrakin antibody; BSF-1 antibody; BSF1 antibody; IGG1 induction factor antibody; IL 4 antibody; IL-4 antibody; IL4 antibody; IL4_HUMAN antibody; Il4e12 antibody; Interleukin 4 antibody; Interleukin 4 variant 2 antibody; Interleukin 4, isoform 1 antibody; Interleukin-4 antibody; Lymphocyte stimulatory factor 1 antibody; MGC79402 antibody; Pitrakinra antibody
Belongs to the IL-4/IL-13 family.
Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.
Chen, Ji et al.
Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome. | Bmc Gastroenterology