IL-17RB Rabbit Polyclonal Antibody (ER1706-26)

UNIPROT #

Q9NRM6

PROTEIN NAME

IL-17RB

SYNONYMS

CRL 4 antibody;CRL4 antibody;Cytokine receptor CRL4 antibody;EVI 27 antibody;EVI27 antibody;IL 17 receptor B antibody;IL 17 receptor homolog 1 antibody;IL 17B receptor antibody;IL 17RB antibody;IL 17Rh1 antibody;IL17BR antibody;IL17RB antibody;IL17RH1 antibody;Interleukin 17 receptor B antibody;Interleukin 17 receptor homolog 1 antibody;Interleukin 17 receptor homolog antibody;Interleukin 17B receptor antibody;MGC5245 antibody

TISSUE SPECIFICITY

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

SUBCELLULAR LOCATION

Single-pass type I membrane protein. Secreted.

FUNCTION

Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. IL-17RB is a member of the cytokine receptor family and acts as a receptor for the proinflammatory cytokines IL-17B and IL-17E. It may play a role in hematopoietic cell differentiation and growth. IL-17RB expression is high in liver, colon, brain, kidney and testis. IL-17RB is detected in fibroblast-like synoviocytes of rheumatoid arthritis patients.