UNIPROT #

Q9NRM6

PROTEIN NAME

IL17RB

SYNONYMS

CRL 4 antibody; CRL4 antibody; Cytokine receptor CRL4 antibody; EVI 27 antibody; EVI27 antibody; IL 17 receptor B antibody; IL 17 receptor homolog 1 antibody; IL 17B receptor antibody; IL 17RB antibody; IL 17Rh1 antibody; IL17BR antibody; IL17RB antibody; IL17RH1 antibody; Interleukin 17 receptor B antibody; Interleukin 17 receptor homolog 1 antibody; Interleukin 17 receptor homolog antibody; Interleukin 17B receptor antibody; MGC5245 antibody

TISSUE SPECIFICITY

Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.

SUBCELLULAR LOCATION

Single-pass type I membrane protein. Secreted.

FUNCTION

Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. IL-17RB is a member of the cytokine receptor family and acts as a receptor for the proinflammatory cytokines IL-17B and IL-17E. It may play a role in hematopoietic cell differentiation and growth. IL-17RB expression is high in liver, colon, brain, kidney and testis. IL-17RB is detected in fibroblast-like synoviocytes of rheumatoid arthritis patients.