Lane 1: Hela cell lysates
Lane 2: Mouse placenta tissue lysates
Rabbit polyclonal primary
IL12B Rabbit Polyclonal Antibody (ER1803-31)
Synthetic peptide within mouse il12b aa 220-300.
Hela, Mouse placenta tissue lysate.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
CLMF antibody; CLMF p40 antibody; CLMF2 antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; IL 12B antibody; IL-12 subunit p40 antibody; IL-12B antibody; IL12 p40 antibody; IL12B antibody; IL12B_HUMAN antibody; IMD28 antibody; IMD29 antibody; Interleukin 12 beta chain antibody; Interleukin 12 p40 antibody; Interleukin-12 subunit beta antibody; NK cell stimulatory factor chain 2 antibody; NKSF antibody; NKSF2 antibody
Belongs to the IL-12B family.
Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.