IL12B Rabbit Polyclonal Antibody (ER1803-31)

UNIPROT #

P29460

PROTEIN NAME

IL12B

SYNONYMS

CLMF antibody;CLMF p40 antibody;CLMF2 antibody;Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody;IL 12B antibody;IL-12 subunit p40 antibody;IL-12B antibody;IL12 p40 antibody;IL12B antibody;IL12B_HUMAN antibody;IMD28 antibody;IMD29 antibody;Interleukin 12 beta chain antibody;Interleukin 12 p40 antibody;Interleukin-12 subunit beta antibody;NK cell stimulatory factor chain 2 antibody;NKSF antibody;NKSF2 antibody

SEQUENCE SIMILARITIES

Belongs to the IL-12B family.

POST-TRANSLATIONAL MODIFICATION

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.