Recombinant Rabbit monoclonal primary
IL1 beta Recombinant Rabbit Monoclonal Antibody [JJ087-3] (ET1701-39)
Synthetic peptide within c-terminal human il1 beta.
A431, Hela, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Catabolin antibody; H1 antibody; IL 1 antibody; IL 1 beta antibody; IL-1 beta antibody; IL1 BETA antibody; IL1B antibody; IL1B_HUMAN antibody; IL1F2 antibody; Interleukin 1 beta antibody; Interleukin-1 beta antibody; OAF antibody; OTTHUMP00000162031 antibody; Preinterleukin 1 beta antibody; Pro interleukin 1 beta antibody
Belongs to the IL-1 family.
Expressed in activated monocytes/macrophages (at protein level).
Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
Cytoplasm, Lysosome, extracellular exosome, Secreted.
Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.
Lei, B., Liu, J., Yao, Z......
Lei, B., Liu, J., Yao, Z., Xiao, Y., Zhang, X., Zhang, Y., & Xu, J. (2021). NF-κB-Induced Upregulation of miR-146a-5p Promoted Hippocampal Neuronal Oxidative Stress and Pyroptosis via TIGAR in a Model of Alzheimer's Disease. Frontiers in cellular neuroscience, 15, 653881.