UNIPROT #

P01583

PROTEIN NAME

IL1 alpha

SYNONYMS

BAF antibody; FAF antibody; Hematopoietin 1 antibody; Hematopoietin-1 antibody; IL 1 alpha antibody; IL 1A antibody; IL-1 alpha antibody; Il-1a antibody; IL1 ALPHA antibody; IL1 antibody; IL1A antibody; IL1A_HUMAN antibody; IL1F1 antibody; Interleukin 1 alpha antibody; Interleukin-1 alpha antibody; Interleukin1 alpha antibody; LAF antibody; LEM antibody; Preinterleukin 1 alpha antibody; Pro interleukin 1 alpha antibody

SEQUENCE SIMILARITIES

Belongs to the IL-1 family.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.