Applications
-
IHC-P
-
FC
-
WB
REACTIVITY
-
Human
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
IL1 alpha Rabbit Polyclonal Antibody (ER1802-36)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
Human lymph node lysates, Human colon cancer tissue, PC-3M.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein affinity purified
MOLECULAR WEIGHT
31 kDa
Isotype
IgG
APPLICATION DILUTION
-
IHC-P
-
1:400-1:800
-
FC
-
1:50-1:100
-
WB
-
1:500
TARGET
UNIPROT #
PROTEIN NAME
IL1 alpha
SYNONYMS
BAF antibody; FAF antibody; Hematopoietin 1 antibody; Hematopoietin-1 antibody; IL 1 alpha antibody; IL 1A antibody; IL-1 alpha antibody; Il-1a antibody; IL1 ALPHA antibody; IL1 antibody; IL1A antibody; IL1A_HUMAN antibody; IL1F1 antibody; Interleukin 1 alpha antibody; Interleukin-1 alpha antibody; Interleukin1 alpha antibody; LAF antibody; LEM antibody; Preinterleukin 1 alpha antibody; Pro interleukin 1 alpha antibody
SEQUENCE SIMILARITIES
Belongs to the IL-1 family.
SUBCELLULAR LOCATION
Secreted.
FUNCTION
Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.