IL-1 alpha Rabbit Polyclonal Antibody (ER1802-36)

UNIPROT #

P01583

PROTEIN NAME

IL-1 alpha

SYNONYMS

BAF antibody;FAF antibody;Hematopoietin 1 antibody;Hematopoietin-1 antibody;IL 1 alpha antibody;IL 1A antibody;IL-1 alpha antibody;Il-1a antibody;IL1 ALPHA antibody;IL1 antibody;IL1A antibody;IL1A_HUMAN antibody;IL1F1 antibody;Interleukin 1 alpha antibody;Interleukin-1 alpha antibody;Interleukin1 alpha antibody;LAF antibody;LEM antibody;Preinterleukin 1 alpha antibody;Pro interleukin 1 alpha antibody

SEQUENCE SIMILARITIES

Belongs to the IL-1 family.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.