Rabbit polyclonal primary
IL-7R-alpha Rabbit Polyclonal Antibody (ER1706-68)
Recombinant protein within human il-7r-alpha aa 222-392.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
CD 127 antibody; CD127 antibody; CD127 antigen antibody; CDw127 antibody; IL 7R alpha antibody; IL 7R antibody; IL-7 receptor subunit alpha antibody; IL-7R subunit alpha antibody; IL-7R-alpha antibody; IL-7RA antibody; IL7R antibody; IL7RA antibody; IL7RA_HUMAN antibody; IL7Ralpha antibody; ILRA antibody; Interleukin 7 receptor alpha chain antibody; Interleukin 7 receptor antibody; Interleukin 7 receptor isoform H5 6 antibody; Interleukin-7 receptor subunit alpha antibody
Belongs to the type I cytokine receptor family. Type 4 subfamily.
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
Interleukin 7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor g chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2), originally called 4PS.