UNIPROT #

P16871

PROTEIN NAME

IL-7R-alpha

SYNONYMS

CD 127 antibody; CD127 antibody; CD127 antigen antibody; CDw127 antibody; IL 7R alpha antibody; IL 7R antibody; IL-7 receptor subunit alpha antibody; IL-7R subunit alpha antibody; IL-7R-alpha antibody; IL-7RA antibody; IL7R antibody; IL7RA antibody; IL7RA_HUMAN antibody; IL7Ralpha antibody; ILRA antibody; Interleukin 7 receptor alpha chain antibody; Interleukin 7 receptor antibody; Interleukin 7 receptor isoform H5 6 antibody; Interleukin-7 receptor subunit alpha antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 4 subfamily.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.

SUBCELLULAR LOCATION

Secretion protein/Cell membrane

FUNCTION

The IL-7 cytokine plays a major role in the in vivo maintenance of polyclonal naive and memory T cells, positively regulating the survival, differentiation and proliferation of thymocyte and peripheral T lymphocyte populations. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4,IL-7, IL-9 and IL-15 receptors. Soluble forms of the IL-7 Rα have been reported.