CD127 Rabbit Polyclonal Antibody (0804-9)

UNIPROT #

P16871

PROTEIN NAME

CD127

SYNONYMS

CD 127 antibody;CD127 antibody;CD127 antigen antibody;CDw127 antibody;IL 7R alpha antibody;IL 7R antibody;IL-7 receptor subunit alpha antibody;IL-7R subunit alpha antibody;IL-7R-alpha antibody;IL-7RA antibody;IL7R antibody;IL7RA antibody;IL7RA_HUMAN antibody;IL7Ralpha antibody;ILRA antibody;Interleukin 7 receptor alpha chain antibody;Interleukin 7 receptor antibody;Interleukin 7 receptor isoform H5 6 antibody;Interleukin-7 receptor subunit alpha antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 4 subfamily.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.

SUBCELLULAR LOCATION

Secretion protein, Cell membrane, cytosol, nucleoplasm.

FUNCTION

The IL-7 cytokine plays a major role in the in vivo maintenance of polyclonal naive and memory T cells, positively regulating the survival, differentiation and proliferation of thymocyte and peripheral T lymphocyte populations. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4,IL-7, IL-9 and IL-15 receptors. Soluble forms of the IL-7 Rα have been reported.