IL-4R Recombinant Rabbit Monoclonal Antibody [PSH10-86] (HA723253)

UNIPROT #

P24394

PROTEIN NAME

IL-4R

SYNONYMS

CD124 antibody;IL 4R alpha antibody;IL-4 receptor subunit alpha antibody;IL-4-binding protein antibody;IL-4R subunit alpha antibody;IL-4R-alpha antibody;IL-4RA antibody;IL4-BP antibody;Il4r antibody;IL4R nirs variant 1 antibody;IL4RA antibody;IL4RA_HUMAN antibody;Interleukin 4 receptor alpha chain antibody;Interleukin 4 receptor antibody;sIL4Ralpha/prot antibody;Soluble IL-4 receptor subunit alpha antibody;Soluble IL-4R-alpha antibody;Soluble interleukin-4 receptor subunit alpha antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor). This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. Interactions of IL-4 with TNFα promote structural changes to vascular endothelial cells, thus playing an important role in tissue inflammation.