IL-17 Rabbit Polyclonal Antibody (ER1706-91)
Catalog# ER1706-91
Rabbit Polyclonal to IL-17
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WB
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IHC-P
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FC
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Human
Lysates/proteins at 50 ng/Lane.
Predicted band size: 18 kDa
Observed band size: 16 kDa
Exposure time: 10 seconds; ECL: K1801;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ER1706-91) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Rabbit polyclonal primary
Product Name
IL-17 Rabbit Polyclonal Antibody (ER1706-91)
Immunogen
Synthetic peptide within human il-17 aa 60-109 / 155.
Host
Rabbit
Positive Control
Human tonsil tissue, Jurkat.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:1,000
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FC
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1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 18 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
IL-17
SYNONYMS
CTLA 8 antibody;CTLA-8 antibody;CTLA8 antibody;Cytotoxic T lymphocyte associated antigen 8 antibody;Cytotoxic T lymphocyte associated protein 8 antibody;Cytotoxic T lymphocyte associated serine esterase 8 antibody;Cytotoxic T-lymphocyte-associated antigen 8 antibody;IL 17A antibody;IL-17 antibody;IL-17A antibody;IL17 antibody;IL17_HUMAN antibody;Il17a antibody;Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody;Interleukin 17A antibody;Interleukin-17A antibody;Interleukin17 antibody;Interleukin17A antibody;OTTHUMP00000016597 antibody;OTTMUSP00000046003 antibody
SEQUENCE SIMILARITIES
Belongs to the IL-17 family.
TISSUE SPECIFICITY
Restricted to activated memory T-cells.
POST-TRANSLATIONAL MODIFICATION
Found both in glycosylated and nonglycosylated forms.
SUBCELLULAR LOCATION
Secreted.
FUNCTION
Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.
CITATIONS
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Lamina propria interleukin 17 A aggravates natural killer T‐cell activation in autoimmune hepatitis
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IHC
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Mouse
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Citation
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