IL-12RB1 Rabbit Polyclonal Antibody (HA500321)

UNIPROT #

P42701

PROTEIN NAME

IL-12RB1

SYNONYMS

CD212 antibody;cluster of differentiation 212 antibody;I12R1_HUMAN antibody;IL-12 receptor beta component antibody;IL-12 receptor subunit beta-1 antibody;IL-12R subunit beta-1 antibody;IL-12R-beta-1 antibody;IL-12RB1 antibody;IL12 receptor beta component antibody;IL12RB antibody;Il12rb1 antibody;IMD3 antibody;IMD30 antibody;Interleukin 12 receptor beta 1 chain antibody;Interleukin 12 receptor subunit beta 1 antibody;Interleukin-12 receptor subunit beta-1 antibody;MGC34454 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor. IL12RB1, is the name of its human gene. IL-12Rβ1 is also known as CD212. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin-12 (IL-12) with a low affinity, and is part of the IL-12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL-12 binding activity. The coexpression of this and IL-12Rβ2 protein was shown to lead to the formation of high-affinity IL-12 binding sites and reconstitution of IL-12 dependent signaling. IL-12Rβ1 can also bind interleukin-23 (IL-23) as part of the IL-23 receptor complex. This complex forms a disulfide-linked oligomer, which is required for its IL-23 binding activity. The coexpression of this and IL-23R protein was shown to lead to the formation of IL-23 binding sites. Various mutations in this gene were found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.