IL-12A Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH16-10] (HA723815)

UNIPROT #

P29459

PROTEIN NAME

IL-12A

SYNONYMS

CLMF antibody;CLMF p35 antibody;Cytotoxic lymphocyte maturation factor 1 p35 antibody;Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody;IL 12 subunit p35 antibody;IL 12A antibody;IL-12 subunit p35 antibody;IL-12A antibody;IL12A antibody;IL12A_HUMAN antibody;IL35 antibody;IL35 subunit antibody;Interleukin 12 alpha chain antibody;Interleukin 12 p35 antibody;Interleukin 12 subunit alpha antibody;Interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) antibody;Interleukin-12 subunit alpha antibody;Natural killer cell stimulatory factor 1 35 kD subunit antibody;NF cell stimulatory factor chain 1 antibody;NFSK antibody;NK cell stimulatory factor chain 1 antibody;NKSF1 antibody;P35 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene. This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of interferon gamma (IFN-γ), and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.