IKB beta Recombinant Rabbit Monoclonal Antibody [SN0648] (ET1611-1)

UNIPROT #

Q15653

PROTEIN NAME

IKB beta

SYNONYMS

I kappa B beta antibody;I-kappa-B-beta antibody;IkappaBbeta antibody;IKB beta antibody;IkB-B antibody;IkB-beta antibody;IKBB antibody;IKBB_HUMAN antibody;IkBbeta antibody;NF kappa BIB antibody;NF-kappa-B inhibitor beta antibody;NF-kappa-BIB antibody;Nfkbib antibody;Thyroid receptor interacting protein 9 antibody;Thyroid receptor-interacting protein 9 antibody;TR interacting protein 9 antibody;TR-interacting protein 9 antibody;TRIP-9 antibody;TRIP9 antibody

SEQUENCE SIMILARITIES

Belongs to the NF-kappa-B inhibitor family.

TISSUE SPECIFICITY

Expressed in all tissues examined.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).