IGJ Recombinant Rabbit Monoclonal Antibody [PD00-89] (HA721205)

UNIPROT #

P01591

PROTEIN NAME

IGJ

SYNONYMS

IGCJ antibody;IGJ_HUMAN antibody;Immunoglobulin J chain antibody;Immunoglobulin J polypeptide linker protein for immunoglobulin alpha and mu polypeptides antibody;immunoglobulin joining chain antibody;JCH antibody;JCHAIN antibody;Joining chain of multimeric IgA and IgM antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

A J chain is a protein component of the antibodies IgM and IgA. It is a 137 residue polypeptide, encoded by the IGJ gene. The J Chain is required for IgM or IgA to be secreted into mucosa. As part of a polymeric immunoglobulin (pIg), the J-chain is essential for binding of pIg to the pIgR, which forms the secretory component upon excretion of the secretory pIg by epithelial cells. This binding facilitates transport of the J-chain positive pIg molecules from the basal to the apical sides of epithelial cells. Because IgM and IgA are the only two types of antibody that polymerize, initial hypotheses stated that J chain was required for polymerization. However, it was subsequently found that IgM is able to polymerize in the absence of J chain as both a pentamer and a hexamer, however, both of these exist to lesser numbers in organisms lacking J chains. In such cases, there are also fewer IgA dimers. The J-chain also plays a role in the activation of complement. J-chain negative IgM hexamers are 15-20 times more effective at activating complement than J-chain positive IgM pentamers. A consequence of this lack of complement activation is it allows J-chain positive pIgM to bind antigens without causing excessive damage to epithelial membranes through complement activation.