PRODUCT CODE: ET7106-63

IGFBP2 Recombinant Rabbit Monoclonal Antibody [JU37-46] (ET7106-63)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

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Western blot analysis of IGFBP2 on Human serum (1) and NCCIT (2) lysates using anti-IGFBP2 antibody at 1/500 dilution.
  • Western blot analysis of IGFBP2 on Human serum (1) and NCCIT (2) lysates using anti-IGFBP2 antibody at 1/500 dilution.
  • Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-IGFBP2 antibody. Counter stained with hematoxylin.
Western blot analysis of IGFBP2 on Human serum (1) and NCCIT (2) lysates using anti-IGFBP2 antibody at 1/500 dilution.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

IGFBP2 Recombinant Rabbit Monoclonal Antibody [JU37-46] (ET7106-63)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human serum lysate, NCCIT, human liver tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JU37-46

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

35 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

IGFBP2

SYNONYMS

BP 2 antibody; BP2 antibody; IBP 2 antibody; IBP-2 antibody; IBP2 antibody; IBP2_HUMAN antibody; IGF binding protein 2 antibody; IGF BP53 antibody; IGF-binding protein 2 antibody; IGFBP 2 antibody; IGFBP-2 antibody; IGFBP2 antibody; IGFBP53 antibody; Insulin like growth factor binding protein 2 36kDa antibody; Insulin like growth factor binding protein 2 antibody; Insulin like growth factor-binding protein 2 precursor antibody; Insulin-like growth factor-binding protein 2 antibody

POST-TRANSLATIONAL MODIFICATION

O-glycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain.