Applications
-
WB
-
IHC-P
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Recombinant Rabbit monoclonal primary
Product Name
IGFBP2 Recombinant Rabbit Monoclonal Antibody [JU37-46] (ET7106-63)
Immunogen
Recombinant protein
Host
Rabbit
Positive Control
Human serum lysate, NCCIT, human liver tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JU37-46
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
35 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:2,000
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
IGFBP2
SYNONYMS
BP 2 antibody; BP2 antibody; IBP 2 antibody; IBP-2 antibody; IBP2 antibody; IBP2_HUMAN antibody; IGF binding protein 2 antibody; IGF BP53 antibody; IGF-binding protein 2 antibody; IGFBP 2 antibody; IGFBP-2 antibody; IGFBP2 antibody; IGFBP53 antibody; Insulin like growth factor binding protein 2 36kDa antibody; Insulin like growth factor binding protein 2 antibody; Insulin like growth factor-binding protein 2 precursor antibody; Insulin-like growth factor-binding protein 2 antibody
POST-TRANSLATIONAL MODIFICATION
O-glycosylated.
SUBCELLULAR LOCATION
Secreted.
FUNCTION
The Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain.