Recombinant Rabbit monoclonal primary
IGF2 Recombinant Rabbit Monoclonal Antibody [JJ092-3] (ET1701-88)
293, 293T, Hela, HepG2, human liver cancer tissue, human colon cancer tissue, human breast carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
C11orf43 antibody; IGF 2 antibody; IGF II antibody; IGF-II antibody; IGF2 antibody; IGF2_HUMAN antibody; IGFII antibody; INSIGF antibody; insulin like growth factor 2 (somatomedin A) antibody; Insulin like Growth Factor 2 antibody; Insulin like growth factor II antibody; Insulin like growth factor II precursor antibody; Insulin like growth factor type 2 antibody; pp9974 antibody; Preptin antibody; putative insulin like growth factor II associated protein antibody; Somatomedin A antibody; Somatomedin-A antibody
Belongs to the insulin family.
Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.
During embryogenesis, detected in liver, lung, skeletal muscle and placenta.
O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.; Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
IGF-II (Insulin-like growth factor II; also multiplication-stimulating polypeptide/MSP and somatomedin-A) is a secreted 8 kDa polypeptide that belongs to the insulin family of peptide growth factors. It is part of a complex system of growth and metabolic-regulating proteins that is particularly important during development. It has been associated with nervous system proliferation and differentiation, myelination, adrenal cortical proliferation, and skeletal growth and differentiation. In human, IGF-II is primarily synthesized by the liver, and circulates at high levels in both fetus and adult. In rodent, however, IGF-II levels drop after the perinatal period, an effect attributed to the lack of a key gene promoter. This may indicate that postnatally, IGF-II has either a limited, or local effect only in rodent.