UNIPROT #

P17181

PROTEIN NAME

IFNAR1

SYNONYMS

Alpha type antiviral protein antibody; Antiviral protein, alpha-type antibody; Antiviral protein, beta-type antibody; AVP antibody; Beta type antiviral protein antibody; CRF2-1 antibody; Cytokine receptor class-II member 1 antibody; Cytokine receptor family 2 member 1 antibody; IFN alpha REC antibody; IFN alpha receptor antibody; IFN alpha/beta Receptor alpha antibody; IFN beta receptor antibody; IFN Interferon-beta receptor antibody; IFN-alpha/beta receptor 1 antibody; IFN-R-1 antibody; IFNAR antibody; Ifnar1 antibody; IFNBR antibody; IFRC antibody; INAR1_HUMAN antibody; Interferon (alpha beta and omega) receptor 1 antibody; interferon alpha and beta receptor subunit 1 antibody; Interferon alpha/beta receptor 1 antibody; Interferon alpha/beta receptor alpha chain antibody; Interferon beta receptor 1 antibody; interferon receptor 1 antibody; Interferon-alpha receptor antibody; Type I interferon receptor 1 antibody

SEQUENCE SIMILARITIES

Belongs to the type II cytokine receptor family.

TISSUE SPECIFICITY

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated, leading to its internalization and degradation. Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex.; Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination. Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Phosphorylated on tyrosine residues in response to interferon.; Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.

SUBCELLULAR LOCATION

Endosome. Cell membrane.

FUNCTION

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.