iFluor™ 488 Conjugated Sodium Potassium ATPase Recombinant Rabbit Monoclonal Antibody [ST0533] (HA720174F)

UNIPROT #

P05023

PROTEIN NAME

Sodium Potassium ATPase

SYNONYMS

ATPase Na+/K+ transporting alpha antibody;adenosinetriphosphatase antibody;AT1A1_HUMAN antibody;ATP1A1 antibody;ATP1A4 antibody;ATP1AL2 antibody;ATP1B antibody;ATP1B1 antibody;ATPase Na+/K+ transporting alpha 1 polypeptide antibody;ATPase Na+/K+ transporting alpha 4 polypeptide antibody;ATPase Na+/K+ transporting beta 1 polypeptide antibody;ATPase, Na+/K+ transporting, alpha polypeptide-like 2 antibody;ATPase, Na+/K+ transporting, beta 1 polypeptide antibody;Beta 1-subunit of Na(+),K(+)-ATPase antibody;Na(+)/K(+) ATPase alpha-1 subunit antibody;Na(+)/K(+) ATPase alpha-4 subunit antibody;Na+, K+ ATPase alpha subunit antibody;Na+/K+ ATPase 1 antibody;Na+/K+ ATPase 4 antibody;Na+/K+ ATPase, alpha-D polypeptide antibody;Na, K-ATPase beta-1 polypeptide antibody;Na, K-ATPase, alpha-A catalytic polypeptide antibody;Na,K-ATPase catalytic subunit alpha-A protein antibody;Na,K-ATPase subunit alpha-C antibody;polypeptide-like 2 antibody;Sodium pump 1 antibody;sodium pump 4 antibody;Sodium pump subunit alpha-1 antibody;sodium pump subunit alpha-4 antibody;sodium pump subunit beta-1 antibody;sodium-potassium ATPase catalytic subunit alpha-1 antibody;sodium-potassium ATPase catalytic subunit alpha-4 antibody;sodium-potassium ATPase subunit beta 1 (non-catalytic) antibody;sodium-potassium ATPase, alpha 4 polypeptide antibody;sodium-potassium-ATPase, alpha 1 polypeptide antibody;Sodium/potassium transporting ATPase alpha 1 chain antibody;Sodium/potassium transporting ATPase subunit beta 1 antibody;sodium/potassium-dependent ATPase beta-1 subunit antibody;sodium/potassium-transporting ATPase alpha-4 chain antibody;sodium/potassium-transporting ATPase beta-1 chain antibody;Sodium/potassium-transporting ATPase subunit alpha-1 antibody;sodium/potassium-transporting ATPase subunit alpha-4 antibody

SEQUENCE SIMILARITIES

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity (By similarity).

SUBCELLULAR LOCATION

Cell membrane, Melanosome.

FUNCTION

The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na⁺/K⁺-ATPase, Na⁺/K⁺ pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na⁺/K⁺-ATPase helps maintain resting potential, affects transport, and regulates cellular volume. It also functions as a signal transducer/integrator to regulate the MAPK pathway, reactive oxygen species (ROS), as well as intracellular calcium. In fact, all cells expend a large fraction of the ATP they produce (typically 30% and up to 70% in nerve cells) to maintain their required cytosolic Na and K concentrations. For neurons, the Na⁺/K⁺-ATPase can be responsible for up to 3/4 of the cell's energy expenditure. In many types of tissue, ATP consumption by the Na⁺/K⁺-ATPases have been related to glycolysis. This was first discovered in red blood cells (Schrier, 1966), but has later been evidenced in renal cells, smooth muscles surrounding the blood vessels,[6] and cardiac purkinje cells. Recently, glycolysis has also been shown to be of particular importance for Na⁺/K⁺-ATPases in skeletal muscles, where inhibition of glycogen breakdown (a substrate for glycolysis) leads to reduced Na⁺/K⁺-ATPase activity and lower force production.