iFluor™ 488 Conjugated Lamin B1 Recombinant Rabbit Monoclonal Antibody [SI17-07] (HA720171F)

UNIPROT #

P20700

PROTEIN NAME

Lamin B1

SYNONYMS

ADLD antibody;lamin B1 antibody;Lamin-B1 antibody;LMN antibody;LMN2 antibody;LMNB antibody;Lmnb1 antibody;LMNB1_HUMAN antibody;MGC111419 antibody;OTTHUMP00000159218 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

SUBCELLULAR LOCATION

Nucleus inner membrane.

FUNCTION

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology as components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family.