iFluor™ 488 Conjugated FOXO1A Recombinant Rabbit Monoclonal Antibody [SU33-01] (HA720161F)

UNIPROT #

Q12778

PROTEIN NAME

FOXO1A

SYNONYMS

FKH 1 antibody;FKH1 antibody;FKHR antibody;Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody;Forkhead box O1 antibody;Forkhead box protein O1 antibody;Forkhead box protein O1A antibody;Forkhead in rhabdomyosarcoma antibody;Forkhead, Drosophila, homolog of, in rhabdomyosarcoma antibody;FoxO transcription factor antibody;foxo1 antibody;FOXO1_HUMAN antibody;FOXO1A antibody;OTTHUMP00000018301 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1, which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins, leading to FKHR-induced gene-specific transcriptional activation. FKHR, also designated forkhead box protein O1A (FOXO1), is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7, including the paired box and homeodomain DNA-binding domains, with the carboxy-terminus of FKHR, which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes.