iFluor™ 488 Conjugated Collagen VI Recombinant Rabbit Monoclonal Antibody [SD83-03] (HA720155F)

UNIPROT #

P12109

PROTEIN NAME

Collagen VI

SYNONYMS

Alpha 1 (VI) chain (61 AA) antibody;CO6A1_HUMAN antibody;COL6A1 antibody;COL6A2 antibody;COL6A3 antibody;Collagen alpha 2(VI) chain antibody;Collagen alpha 3(VI) chain antibody;Collagen alpha-1(VI) chain antibody;Collagen type VI alpha 1 antibody;Collagen type VI alpha 2 antibody;Collagen type VI alpha 3 antibody;Collagen VI alpha 1 polypeptide antibody;Collagen VI alpha 2 polypeptide antibody;Collagen VI alpha 3 polypeptide antibody;CollagenVI antibody;Human mRNA for collagen VI alpha 2 C terminal globular domain antibody;OPLL antibody;PP3610 antibody

SUBCELLULAR LOCATION

Extracellular matrix.

FUNCTION

This antibody is well suited to detect extracellular matrix proteins in normal as well as disease state tissues. Disruption of tissue organization is the hallmark of neoplasia. Malignant lesions can be distinguished from benign by examining the breakdown of basement membranes and loss of 3-dimensional architecture. Malignant cells are presumed to use matrix metalloproteases to degrade barriers created by the extracellular matrix which then allows metastasis to occur. Collagenases, stomelysins and gelatinases can collectively degrade all of the various components of the extracellular matrix, including fibrillar and non-fibrillar collagens and basement membrane glycoproteins.