IFITM1 Rabbit Polyclonal Antibody (ER1902-77)

UNIPROT #

P13164

PROTEIN NAME

IFITM1

SYNONYMS

9-27 antibody;CD 225 antibody;CD 225 antigen antibody;CD225 antibody;CD225 antigen antibody;Dispanin subfamily A member 2a antibody;DSPA2a antibody;IFI 17 antibody;IFI17 antibody;IFITM1 antibody;IFM1_HUMAN antibody;Interferon induced protein 17 antibody;interferon induced transmembrane protein 1 (9-27) antibody;Interferon induced transmembrane protein 1 antibody;Interferon inducible protein 9-27 antibody;Interferon-induced protein 17 antibody;Interferon-induced transmembrane protein 1 antibody;Interferon-inducible protein 9-27 antibody;Leu 13 antibody;Leu 13 antigen antibody;Leu-13 antigen antibody;LEU13 antibody

SEQUENCE SIMILARITIES

Belongs to the CD225/Dispanin family.

TISSUE SPECIFICITY

Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.

POST-TRANSLATIONAL MODIFICATION

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.