ICOS Recombinant Rabbit Monoclonal Antibody [JE39-99] (HA722247)

UNIPROT #

Q9WVS0

PROTEIN NAME

ICOS

SYNONYMS

Activation inducible lymphocyte immunomediatory molecule antibody;Activation-inducible lymphocyte immunomediatory molecule antibody;AILIM antibody;CD278 antibody;CD278 antigen antibody;CD28-related Protein-1 antibody;CRP1 antibody;CVID1 antibody;ICOS antibody;ICOS_HUMAN antibody;Inducible costimulator antibody;Inducible T cell co stimulator antibody;Inducible T-cell costimulator antibody;MGC39850 antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

Inducible T-cell costimulator (also called CD278) is an immune checkpoint protein that in humans is encoded by the ICOS (Inducible T-cell COStimulator) gene. The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on the surface of immune cells that mediate signalling between them. A surface protein, the ligand, binds specifically to its receptor on another cell, leading to a signalling cascade in that cell. ICOS is a receptor protein expressed on the surface of activated T cells. Its ligand ICOS-L (previously called B7RP-1) is constitutively expressed on B cells. Stimulation of the ICOS receptor on T cells by ICOS-L on B cells is required for the development of follicular helper T (Tfh) cells. ICOS forms homodimers and plays an important role in cell-cell signaling, immune responses and regulation of cell proliferation.