ICAM1 Rabbit Polyclonal Antibody (ER131207)
Catalog# ER131207
Rabbit Polyclonal to ICAM1
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WB
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IF-Cell
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IHC-P
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FC
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Human
Positive control:
Lane 1: Raji cell lysate
Lane 2: HUVEC cell lysate
Lane 3: K562 cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
ICAM1 Rabbit Polyclonal Antibody (ER131207)
Immunogen
Synthetic peptide within human icam1 aa 483-532 / 532.
Host
Rabbit
Positive Control
Raji cell lysate, HUVEC cell lysate, K562 cell lysate, human tonsil tissue, Hela.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IF-Cell
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1:200
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IHC-P
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1:200
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FC
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1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 58 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
ICAM1
SYNONYMS
Antigen identified by monoclonal antibody;BB2 antibody;BB 2 antibody;BB2 antibody;CD 54 antibody;CD_antigen=CD54 antibody;CD54 antibody;Cell surface glycoprotein P3.58 antibody;Human rhinovirus receptor antibody;ICAM 1 antibody;ICAM-1 antibody;ICAM1 antibody;ICAM1_HUMAN antibody;intercellular adhesion molecule 1 (CD54), human rhinovirus receptor antibody;Intercellular adhesion molecule 1 antibody;Major group rhinovirus receptor antibody;MALA 2 antibody;MALA2 antibody;MyD 10 antibody;MyD10 antibody;P3.58 antibody;Surface antigen of activated B cells, BB2 antibody
SEQUENCE SIMILARITIES
Belongs to the immunoglobulin superfamily. ICAM family.
POST-TRANSLATIONAL MODIFICATION
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
SUBCELLULAR LOCATION
Membrane.
FUNCTION
ICAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the protein. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor (TNF) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. More recently, ICAM-1 has been characterized as a site for the cellular entry of human rhinovirus. ICAM-1 and soluble ICAM-1 have antagonistic effects on the tight junctions forming the blood-testis barrier, thus playing a major role in spermatogenesis. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH).
CITATIONS
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Sun, X., Mu, X., Li, F., Wang, Y., Yang, X., & Guo, Q.
Roles of PADI4 in the expression of cytokines involved in inflammation and adhesion in differentiated NB4 cells treated with ATRA
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WB
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Human
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Citation
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He Jia,et al
Unveiling the Impact of Hemodynamics on Endothelial Inflammation-Mediated Hepatocellular Carcinoma Metastasis Using a Biomimetic Vascular Flow Model
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WB
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IF
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Human
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Citation
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