ICAM1 Mouse Monoclonal Antibody [F11-A4] (M1505-7)

UNIPROT #

P05362

PROTEIN NAME

ICAM1

SYNONYMS

Antigen identified by monoclonal antibody;BB2 antibody;BB 2 antibody;BB2 antibody;CD 54 antibody;CD_antigen=CD54 antibody;CD54 antibody;Cell surface glycoprotein P3.58 antibody;Human rhinovirus receptor antibody;ICAM 1 antibody;ICAM-1 antibody;ICAM1 antibody;ICAM1_HUMAN antibody;intercellular adhesion molecule 1 (CD54), human rhinovirus receptor antibody;Intercellular adhesion molecule 1 antibody;Major group rhinovirus receptor antibody;MALA 2 antibody;MALA2 antibody;MyD 10 antibody;MyD10 antibody;P3.58 antibody;Surface antigen of activated B cells, BB1 antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. ICAM family.

POST-TRANSLATIONAL MODIFICATION

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

ICAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the protein. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor (TNF) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. More recently, ICAM-1 has been characterized as a site for the cellular entry of human rhinovirus. ICAM-1 and soluble ICAM-1 have antagonistic effects on the tight junctions forming the blood-testis barrier, thus playing a major role in spermatogenesis. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.