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Human Uteroglobin, C-His Tag Protein (HA211490)

Price: Regular price $129.00

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Catalog# HA211490

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  • Human

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Product Details

Product Type

Protein

Product Name

Human Uteroglobin, C-His Tag Protein (HA211490)

Predicted molecular mass

9.7 kD

Protein construction description

A DNA sequence encoding the human Uteroglobin protein (P11684) (Glu 22-Asn 91) was expressed with a His tag at the C-terminus.

Accession

P11684

Protein construction

Uteroglobin (22-91) | His

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

SCGB1A1 also named CC10. Clara cell 10 (CC10) protein, a homologue of rabbit uteroglobin, is a phospholipase A2 inhibitor. CC10 is regulated by AP-1, octamer, and hepatocyte nuclear factor-3 (HNF-3) family transcription factors. CC10 expression changes in relation to the ovarian menstrual cycle, and expression in human endometrium may be stimulated by progesterone, suggesting that CC10 may regulate eicosanoid levels in the human uterus. CC10 is expressed in nonciliated airway epithelial cells in the lung and in urogenital secretions. CC10 is involved in modulating inflammation in airway passages and may play a role in asthma. Overexpression of CC10 in the non-small cell lung cancer cell line A549 was shown to result in the near absence of MMP-2 and MMP-9 matrix metalloproteinases and a reduction in invasiveness, indicating that loss of CC10 may contribute to carcinogenesis.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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