Human Serum Albumin Mouse Monoclonal Antibody [8-A3] (M0809-4)

UNIPROT #

P02768

PROTEIN NAME

Human Serum Albumin

SYNONYMS

alb antibody;ALBU_HUMAN antibody;Albumin (32 AA) antibody;Albumin (AA 34) antibody;Albumin antibody;Analbuminemia antibody;Bisalbuminemia antibody;Cell growth inhibiting protein 42 antibody;DKFZp779N1935 antibody;Dysalbuminemic hyperthyroxinemia antibody;Growth inhibiting protein 20 antibody;HSA antibody;Hyperthyroxinemia dysalbuminemic antibody;PRO0883 antibody;PRO0903 antibody;PRO1341 antibody;Serum albumin antibody

SEQUENCE SIMILARITIES

Belongs to the ALB/AFP/VDB family.

TISSUE SPECIFICITY

Plasma.

POST-TRANSLATIONAL MODIFICATION

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.; Glycated in diabetic patients.; Phosphorylated by FAM20C in the extracellular medium.; Acetylated on Lys-223 by acetylsalicylic acid.

SUBCELLULAR LOCATION

Secreted

FUNCTION

HSA is the most common protein in serum. It is produced in the liver and the concentration in serum is 35-50 mg/ml. HSA consists of a single polypeptide chain of 584 aminoacids, stabilized by 17 disulfide bridges. HSA is often used as a carrier molecule because of its binding capacity, and thus mainly functions as the regulator of the colloidal osmotic pressure of the blood. HSA binds a wide variety of hydrophobic ligands including fatty acids, bilirubin, thyroxine and hemin.