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Human M-CSFR/CSF1R/CD115, Tag Free (ECD) Protein (HA211149)

Price: Regular price $379.00

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Catalog# HA211149

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  • Human

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Product Details

Product Type

Protein

Product Name

Human M-CSFR/CSF1R/CD115, Tag Free (ECD) Protein (HA211149)

Predicted molecular mass

55.5 kD

Protein construction description

A DNA sequence encoding the human M-CSFR/CSF1R/CD115 protein (P07333-1) (Ile 20-Pro 517) was expressed with tag free.

Accession

P07333-1

Protein construction

M-CSFR/CSF1R/CD115 (20-517)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS). CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling is necessary for the survival, proliferation, and differentiation of many myeloid cell types in vivo and in vitro. CSF1R signaling is involved in many diseases and is targeted in therapies for cancer, neurodegeneration, and inflammatory bone diseases.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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