Human IL-8 Recombinant Rabbit Monoclonal Antibody [PS01-22] (HA722099)

UNIPROT #

P10145

PROTEIN NAME

Human IL-8

SYNONYMS

(Ala-IL-8)77 antibody;(Ser-IL-8)72 antibody;9E3 antibody;Beta thromboglobulin like protein antibody;C-X-C motif chemokine 8 antibody;CEF-4 antibody;chemokine, CXC motif, ligand 8 antibody;CXCL8 antibody;Emoctakin antibody;GCP-1 antibody;GCP/IL-8 protein I antibody;GCP/IL-8 protein II antibody;GCP/IL-8 protein III antibody;GCP/IL-8 protein IV antibody;GCP/IL-8 protein V antibody;GCP/IL-8 protein VI antibody;GCP1 antibody;Granulocyte chemotactic protein 1 antibody;IL-8 antibody;IL-8(1-77) antibody;IL-8(9-77) antibody;IL8 antibody;IL8/NAP1 form I antibody;IL8/NAP1 form II antibody;IL8/NAP1 form III antibody;IL8/NAP1 form IV antibody;IL8/NAP1 form V antibody;IL8/NAP1 form VI antibody;IL8_HUMAN antibody;Inteleukin 8 antibody;LECT antibody;LUCT antibody;Lymphocyte-derived neutrophil-activating factor antibody;LYNAP antibody;MDNCF antibody;MDNCF-b antibody;MDNCF-c antibody;MONAP antibody;Monocyte derived neutrophil activating peptide antibody;Monocyte derived neutrophil chemotactic factor antibody;Monocyte-derived neutrophil chemotactic factor antibody;Monocyte-derived neutrophil-activating peptide antibody;NAF antibody;NAP 1 antibody;NAP-1 antibody;NAP1 antibody;Neutrophil activating peptide 1 antibody;Neutrophil activating protein 1 antibody;Neutrophil-activating factor antibody;Neutrophil-activating protein 1 antibody;Protein 3 10C antibody;Protein 3-10C antibody;SCYB 8 antibody;SCYB8 antibody;Small inducible cytokine subfamily B member 8 antibody;T cell chemotactic factor antibody;T-cell chemotactic factor antibody;TSG 1 antibody;TSG1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q.