Human IgM Recombinant Rabbit Monoclonal Antibody [JF84-09] (ET1702-81)

UNIPROT #

P01871

PROTEIN NAME

Human IgM

SYNONYMS

Immunoglobin heavy chain constant region mu edit item name - Immunoglobin heavy chain mu constant region antibody;Immunoglobin heavy chain constant region mu antibody;AGM1 antibody;Constant region of heavy chain of IgM antibody;DKFZp686I15196 antibody;DKFZp686I15212 antibody;FLJ00385 antibody;Ig mu chain C region antibody;IGHM antibody;IgM heavy chain constant region antibody;Immunoglobin heavy constant mu antibody;Immunoglobulin mu antibody;MGC104996 antibody;MGC52291 antibody;MU antibody;VH antibody

SUBCELLULAR LOCATION

Secreted, Cell membrane.

FUNCTION

Immunoglobulin M (IgM) is one of several isotypes of antibody (also known as immunoglobulin) that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. In humans and other mammals that have been studied, Plasmablasts residing in the spleen are the main source for specific IgM production. IgM interacts with several other physiological molecules: IgM can bind complement component C1 and activate the classical pathway, leading to opsonization of antigens and cytolysis; IgM binds to the polyimmunoglobulin receptor (pIgR) in a process that brings IgM to mucosal surfaces, such as the gut lumen and into breast milk. This binding depends on J chain; Two other Fc receptors that bind IgM—Fcα/µ-R and Fcµ-R -- have been detected. Fcα/µ-R, like pIgR, binds polymeric IgM and IgA. Fcα/µ-R can mediate endocytosis, and its expression in the gut suggests a role in mucosal immunity. Fcµ-R (formerly known as Toso/Faim3) binds IgM exclusively and can mediate cellular uptake of IgM-conjugated antigen.