Human Iambda light chain Mouse Monoclonal Antibody [36-59] (M0806-2)

UNIPROT #

P0CG04

PROTEIN NAME

Human Iambda light chain

SYNONYMS

Bence Jones protein antibody;BJP antibody;Constant region of lambda light chains antibody;Ig lambda chain C regions antibody;ig lambda-6 chain C region antibody;IGLC 1 antibody;IGLC 2 antibody;IGLC 3 antibody;IGLC antibody;IGLC1 antibody;IGLC2 antibody;IGLC3 antibody;IGLC6 antibody;IGLV antibody;Immunoglobulin lambda constant 1 antibody;Immunoglobulin lambda constant regin 1 antibody;immunoglobulin lambda gene cluster antibody;Immunoglobulin lambda locus antibody;Immunoglobulin lambda variable cluster antibody;Immunoglobulin: lambda light chain antibody;Mcg marker antibody;Paraprotein antibody

SUBCELLULAR LOCATION

Cell membrane, Immunoglobulin, Membrane, Secreted

FUNCTION

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.