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Human Granzyme K, Tag Free Protein (HA211391)

Price: Regular price $129.00

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Catalog# HA211391

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  • Human

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Product Details

Product Type

Protein

Product Name

Human Granzyme K, Tag Free Protein (HA211391)

Predicted molecular mass

26.2 kD

Protein construction description

A DNA sequence encoding the human Granzyme K protein (P49863) (Ile 27-Asn 264) was expressed with a His tag at the C-terminus.

Accession

P49863

Protein construction

Granzyme K (27-264)

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

Granzyme K (GzmK) is a serine protease that sits in the dense-core granules of cytotoxic T lymphocytes and NK cells. While its gene neighbors encode granzymes A–C, GzmK stands out by lacking the N-linked glycosylation motifs that decorate most family members; this minimalist design keeps it stable at the low pH of the granule and allows it to emerge in an immediately active form once perforin has punched entry holes in a target cell. Inside the cytosol, GzmK bypasses the canonical caspase cascade: it clips Bid to tBid, nicks the anti-apoptotic SET complex, and generates single-stranded DNA nicks that push the cell into a swift form of death intermediate between apoptosis and necrosis. In addition, any GzmK that leaks into the extracellular space can process pro-IL-1β and activate PAR-2 on macrophages and endothelial cells, turning a private hit into a broader inflammatory alert.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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