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Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein (HA210945)

Price: Regular price $389.00

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Catalog# HA210945

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  • Human

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Product Details

Product Type

Protein

Product Name

Human GITR/TNFRSF18/AITR, C-Flag Tag (ECD) Protein (HA210945)

Predicted molecular mass

16.2 kD

Protein construction description

A DNA sequence encoding the human GITR/TNFRSF18/AITR protein (Q9Y5U5-1) (Gln 26-Pro 162) was expressed with a Flag tag at the C-terminus.

Accession

Q9Y5U5-1

Protein construction

GITR/TNFRSF18/AITR (26-162) | Flag

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Human

Background

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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