Human CDCP1 enzyme-linked immunoassay kit(EH0083)

UNIPROT #

Q9H5V8

PROTEIN NAME

CDCP1

SYNONYMS

CUB domain-containing protein 1 Membrane glycoprotein gp140 Subtractive immunization M plus HEp3-associated 135 kDa protein (SIMA135) Transmembrane and associated with src kinases CD318 CDCP1 TRASK UNQ2486/PRO5773

FUNCTION

CDCP1, also known as SIMA135, is a novel 140 kDa type I transmembrane glycoprotein with three CUB protein-protein interaction domains in its 635 aa extracellular region. The 148 aa cytoplasmic region contains canonical phosphorylation sites for Sre kinase family members and binding sites for SH3 domains. By alternative splicing, a secreted 310 aa residue form of CDCP1 also exists. The amino-terminal region of approximately 265 aa of the type I membrane CDCP1 can also be proteolytically cleaved. CDCP1 is found on the surface of epithelial and bone marrow-derived stem cells. The extracellular region of human CDCP1 shares 84% aa identity with that of the mouse protein.