Human CD16 Recombinant Mouse Monoclonal Antibody [PSH04-95] (HA601340)

UNIPROT #

P08637

PROTEIN NAME

Human CD16

SYNONYMS

CD 16 antibody;CD 16a antibody;CD16 antibody;CD16a antibody;CD16a antigen antibody;CD16B antibody;CD16b antigen antibody;Fc fragment of IgG antibody;Fc fragment of IgG low affinity IIIa receptor (CD16) antibody;Fc fragment of IgG low affinity IIIa receptor antibody;Fc fragment of IgG receptor IIIa antibody;Fc fragment of IgG, low affinity III, receptor (CD16) antibody;Fc fragment of IgG, low affinity III, receptor for (CD16) antibody;Fc fragment of IgG, low affinity IIIa, receptor (CD16) antibody;Fc fragment of IgG, low affinity IIIa, receptor (CD16a) antibody;Fc fragment of IgG, low affinity IIIa, receptor for antibody;Fc fragment of IgG, low affinity IIIb, receptor (CD16b) antibody;Fc fragment of IgG, low affinity IIIb, receptor for (CD16) antibody;Fc gamma R3 antibody;Fc gamma receptor III 2 (CD 16) antibody;Fc gamma receptor III A antibody;Fc gamma receptor IIIA antibody;Fc gamma receptor IIIb (CD 16) antibody;Fc gamma RIII alpha antibody;Fc gamma RIII antibody;Fc gamma RIII beta antibody;Fc gamma RIIIa antibody;Fc gamma RIIIb antibody;Fc of IgG antibody;Fc-gamma receptor III2 (CD 16) antibody;Fc-gamma receptor III2 (CD16) antibody;Fc-gamma receptor IIIb (CD16) antibody;Fc-gamma RIII antibody;Fc-gamma RIII-alpha antibody;Fc-gamma RIIIa antibody;FCG 3 antibody;FCG3 antibody;FCG3A_HUMAN antibody;FCgammaRIIIA antibody;FCGR 3 antibody;FCGR 3A antibody;FCGR3 antibody;FCGR3A antibody;FCGR3A protein antibody;FCGRIII antibody;FCGRIII-2 antibody;FcR 10 antibody;FcR-10 antibody;FcR10 antibody;FcRIII antibody;FcRIIIa antibody;IGFR 3 antibody;IGFR3 antibody;IgG Fc receptor III 1 antibody;IgG Fc receptor III 2 antibody;IgG Fc receptor III-2 antibody;IMD20 antibody;immunoglobulin G Fc receptor III antibody;immunoglobulin G Fc receptor III-2 antibody;Low affinity IIIa receptor antibody;Low affinity immunoglobulin gamma Fc region receptor III A antibody;Low affinity immunoglobulin gamma Fc region receptor III-A antibody;Low affinity immunoglobulin gamma Fc region receptor IIIB antibody;neutrophil-specific antigen NA antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16. CD16 is the type III Fcγ receptor. In humans, it exists in two different forms: FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which have 96% sequence similarity in the extracellular immunoglobulin binding regions. While FcγRIIIa is expressed on mast cells, macrophages, and natural killer cells as a transmembrane receptor, FcγRIIIb is only expressed on neutrophils. In addition, FcγRIIIb is the only Fc receptor anchored to the cell membrane by a glycosyl-phosphatidylinositol (GPI) linker, and also plays a significant role in triggering calcium mobilization and neutrophil degranulation. FcγRIIIa and FcγRIIIb together are able to activate degranulation, phagocytosis, and oxidative burst, which allows neutrophils to clear opsonized pathogens.