Hsp20 Recombinant Rabbit Monoclonal Antibody [SD086-03] (ET1612-81)

UNIPROT #

O14558

PROTEIN NAME

Hsp20

SYNONYMS

epididymis luminal protein 55 antibody;FLJ32389 antibody;Heat shock 20 kDa like protein p20 antibody;Heat shock 20 kDa-like protein p20 antibody;Heat shock protein alpha crystallin related B6 antibody;Heat shock protein beta 6 antibody;Heat shock protein beta-6 antibody;Heat shock protein, 20-KD antibody;Heat-shock 27-KD protein 6 antibody;HEL55 antibody;Hsp20 antibody;HspB6 antibody;HSPB6_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the small heat shock protein (HSP20) family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.; Phosphorylated at Ser-16 by PKA and probably PKD1K; required to protect cardiomyocytes from apoptosis.

SUBCELLULAR LOCATION

Cytoplasm, Secreted, Nucleus.

FUNCTION

The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent poly-peptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the low molecular weight HSPs, the immunophilins and the HSP 110 family. The low molecular weight family includes HSP 10, HSP 20, HSP 27 (Heme Oxygenase 1), HSP 32 and HSP 40. HSP 20 occurs in two complex sizes, dimers and multimers. It is related to stress proteins and occurs most abundantly in skeletal muscle and heart. HSP 20 is considerably shorter at the C-terminus and less polar than other small heat shock proteins.